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Enhancer looping protein LDB1 affects T-ALL cell proliferation by cooperating with master transcription factors [RNA-Seq]

GSE253038 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/10/15 Platform GPL24676
Summary
LIM domain-binding protein 1 (LDB1) is a highly conserved and widely expressed chromatin looping protein that connects enhancer-promoter genes through LIM and LIM homologous domains in various cell types. LDB1 has been confirmed to play a crucial role in various physiological and pathological processes. In our study, we aim to investigate the function and mechanisms of LDB1 in the context of T-cell acute lymphoblastic leukemia (T-ALL). RNA-seq was conducted and the differently expressed genes were revealed in the LDB1-knockdown 6T-CEM and J.gamma1 cells in comparison to control group. Cleavage Under Targets and Tagmentation (CUT&Tag) showed the co-localization of LDB1 with several master transcription factors on chromatin in 6T-CEM cells.
Published in
Enhancer looping protein LDB1 modulates MYB expression in T-ALL cell lines in vitro by cooperating with master transcription factors
Li Y, Zhang Z, Yu J et al. · Journal of experimental & clinical cancer research : CR 2024 · PMID 39385230 · doi:10.1186/s13046-024-03199-1
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Also filed as BioProject PRJNA1063689 and SRA study SRP483290. Searching any of these in the dataset finder brings you back here.

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