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Navel Orange Peel Essential Oil Inhibits the Growth and Progression of Triple Negative Breast Cancer

GSE253079 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/20 Platform GPL24676
Summary
Triple Negative Breast Cancer (TNBC) is a particular type of breast cancer with the highest mortality rate and there has been growing concern about the development of essential oils as potential anti-cancer drugs.This investigation explored the bioactivity and molecular mechanisms of navel orange peel oil (NOPEO) against TNBC cells. By initiating cell cycle block and apoptosis, NOPEO demonstrated potent growth suppressive properties on the TNBC cell lines MDA-MB-231 and MDA-MB-453. NOPEO was also effective in inhibiting the motility of MDA-MB-231 cells and in down-regulating the levels of MMP-9 and MMP-2 proteins. Additionally, NOPEO's inhibitory effects on MDA-MB-231 gene expression were analysed by RNA sequencing. In total, 1376 genes were found to be upregulated and 1335 genes were downregulated after NOPEO treatment. According to KEGG and GO pathways, the differentially expressed genes were related to MAPK, Jak/stat and FoxQ signalling pathways.
Published in
Navel orange peel essential oil inhibits the growth and progression of triple negative breast cancer
Yang C, Zhang W, Xiang S et al. · BMC complementary medicine and therapies 2024 · PMID 38877505 · doi:10.1186/s12906-024-04525-y
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Also filed as BioProject PRJNA1063786 and SRA study SRP483228. Searching any of these in the dataset finder brings you back here.

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