← BioTransfer GEO Dataset Finder
GEO series

METTL14 regulates chondrogenesis through the GDF5–RUNX–extracellular matrix gene axis during limb development [scRNA-seq]

GSE253124 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/04/03 Platform GPL24247
Summary
Mettl14 forms a protein complex that induces m6A methylation on RNA but its roles in mouse limb development remains elusive. Here, the Mettl14 gene was knocked out in a limb bud-specific manner in Mettl14 flox/flox mice with the Prx1 promoter-driven cre. Dissociated cells from day 12.5 (E12.5) embryonic limb buds were applied to scRNA-seq to identify differentially expressed genes in a cell type-specific manner. Samples prepared from Per1cre;Mettl14 wild type/flox and Per1cre;Mettl14 flox/flox mice were labeled as cHet and cKO, respectively.
Published in
METTL14 regulates chondrogenesis through the GDF5-RUNX-extracellular matrix gene axis during limb development
Katoku-Kikyo N, Kawakami H, Cantor M et al. · Nature communications 2025 · PMID 40307229 · doi:10.1038/s41467-025-59346-5
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE253124_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1064080 and SRA study SRP483488. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.