GEO series
Genetic deletion of RUNX1 or RUNX2 in adipocytes enhanced beige fat formation
GSE292084
Mus musculus
Expression profiling by high throughput sequencing
43 samples
2026/02/12
GPL34290
Summary
RUNX1/2 overexpression suppresses critical functions associated with brown adipocyte biology, particularly thermogenesis and cellular respiration. Conversely, deletion of RUNX1 or RUNX2 led to a significant increase in cellular temperature, with DKO cells showing the greatest temperature increase.These findings indicate that RUNX1/2 act as negative regulators of thermogenic adipocyte differentiation and actively suppress the thermogenic gene program and function.
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Paper (PMID 41927567) ↗
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