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Dense ion clouds attracted by supercharged supramolecular polymers boost development of neurons

GSE253178 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/03/01 Platform GPL21103
Summary
Neuronal circuitry is critically dependent on the controlled transport of ions in and out of cells. We report here a strategy to supercharge a nanoscale supramolecular assembly that can harbor a huge concentration of monovalent ions which enhances neuronal development. This was accomplished by embedding a small organic cation in a negatively charged peptide amphiphile nanostructure that leads to full ionization of all monomers without destroying the supramolecular polymer. We cultured mouse and human neurons on the supercharged filaments covered by dense ion clouds and observed rapid neurite branching and functional maturation. Furthermore, rat hippocampal brain slices revealed that the dense ion clouds can increase and sustain the frequency of action potential propagation. Our study has provided a vision for the potential use of synthetic systems to boost neurotransmission.
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Also filed as BioProject PRJNA1064161 and SRA study SRP483407. Searching any of these in the dataset finder brings you back here.

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