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Effects of over-expression of PLEK2 on gene expression in 22RV1 cells

GSE253449 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/09 Platform GPL20301
Summary
We previously found that loss of Plek2 decreased Akt activity and reverted disease phenotypes in hematopoietic system specific Pten knockout mice. Pten knockout mice also show prostate cancer phenotype. Using a well known Pten prostate-specific knockout mouse model, we found that loss of Plek2 also reverted tumorigenesis of prostate cancer via decreasing Akt pathway activity. Furthermore, we found that PLEK2 over-expression increased AKT pathway activity and promoted proliferation in 22RV1 cells which is a kind of prostate cancer cell line. To explore additional pathway which PLEK2 may involve in prostate cancer, we performed RNA sequencing in PLEK2 over-expressed and control 22RV1 cells.
Published in
Pleckstrin-2 Mediates the Activation of AKT in Prostate Cancer and Is Repressed by Androgen Receptor
Han X, Zhang A, Wang P et al. · The American journal of pathology 2024 · PMID 39069167 · doi:10.1016/j.ajpath.2024.07.004
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Also filed as BioProject PRJNA1065822 and SRA study SRP484180. Searching any of these in the dataset finder brings you back here.

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