← BioTransfer GEO Dataset Finder
GEO series

Human CD14+ monocytes from rheumatoid arthritis patients before and after a 3-month period of Upadacitinib treatment

GSE253495 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/04 Platform GPL23227
Summary
Janus Kinase (JAK) inhibitors are small molecules that reversibly inhibit JAK activity and their subsequent intracellular signaling and have become the treatment of choice for diseases with an inflammatory or immune basis. We explored the molecular impact of the JAK inhibitor Upadacitinib on the gene expression of human peripheral blood monocytes from three seropositive rheumatoid arthritis patients. The three patients showed disease improvementatthree months follow-up.
Published in
Macrophage re-programming by JAK inhibitors relies on MAFB
López-Navarro B, Simón-Fuentes M, Ríos I et al. · Cellular and molecular life sciences : CMLS 2024 · PMID 38528207 · doi:10.1007/s00018-024-05196-1
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE253495_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1065894 and SRA study SRP484291. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.