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DNA virus infections shape transposable element activity in vitro and in vivo

GSE253543 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/01 Platform GPL24676
Summary
DUX4 is known to be crucial for TEs induction during zygotic genome activation in early embryonic development. In adults, DUX4 is usually silenced and we previously showed that DUX4 expression is induced by infection with various DNA viruses. We demonstrate binding of DUX4 to TEs upon herpesviral infection and analysis of genes adjacent to TEs shows pathways that are known to be crucial for tumor development. Overexpression of DUX4 significantly induced TEs expression, while its knockout (KO) diminished TEs expression upon HSV-1 infection, underscoring the essential role of DUX4 in TEs activation.
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Also filed as BioProject PRJNA1066262 and SRA study SRP484440. Searching any of these in the dataset finder brings you back here.

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