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FTO alleviates psoriasis-like dermatitis through the regulation of FN1

GSE253791 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/05/31 Platform GPL24676
Summary
FTO was found to inhibit keratinocyte inflammation and proliferation in both in vitro and in vivo settings, independent of m6A demethylase function. RNA-seq was used to identify fibronectin (FN1,FN) as a potential target for FTO. FTO does not rely on demethylase activity to decrease FN1 expression. The anti-inflammatory and anti-proliferative effects of FTO on psoriasis partly depend on FN1. FTO may regulate the skipping of EDA exon in FN1.
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Also filed as BioProject PRJNA1067133 and SRA study SRP484961. Searching any of these in the dataset finder brings you back here.

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