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BET inhibitor Pelabresib and AR inhibitor enzalutamide perturbed pathways in prostate cancer CRPC PDX LuCaP 77CR

GSE253805 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/01/18 Platform GPL24676
Summary
To study the effect of inhibiting AR and HNF1A/HNF4G activity either alone or in combination on the growth of CRPC PDX LuCaP 77CR.
Published in
BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature-positive castration-resistant prostate cancer
Shukla S, Li D, Cho WH et al. · The Journal of clinical investigation 2025 · PMID 40553565 · doi:10.1172/JCI180378
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Direct links to NCBI, no account and no request form: the whole study as GSE253805_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1067152 and SRA study SRP484944. Searching any of these in the dataset finder brings you back here.

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