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Gene expression profile at single cell level in prostate cancer PDX, LucaP 70CR treated with Bromo- and -extraterminal domain (BET) inhibitor Pelabresib and vehicle control

GSE253806 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/18 Platform GPL24676
Summary
We used single-cell RNA-sequencing to evaluate the effect of BET inhibitor, pelabresib on AR and HNF1A/HNF4G regulated transcriptome in prostate cancer PDX
Published in
BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature-positive castration-resistant prostate cancer
Shukla S, Li D, Cho WH et al. · The Journal of clinical investigation 2025 · PMID 40553565 · doi:10.1172/JCI180378
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Also filed as BioProject PRJNA1067151 and SRA study SRP484945. Searching any of these in the dataset finder brings you back here.

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