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Gene expression analysis of hPSC-derived macrophages (iMACs) encountering Streptococcus pneumoniae.

GSE253876 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/05/23 Platform GPL24676
Summary
Purpose: to analyze gene expression changes of iMACs encountering S. pneumoniae. Methods: SMART-seq2 amplified polyA RNA from sorted iMACs in the co-cultures. Results: the transcriptome of iMACs changed after encountering S. pneumoniae. Conclusions: the gene expression profiles of S. pneumoniae stimulated iMACs indicated iMACs undergoing inflammatory response and the immune response was distinct with iMACs encountering other pathogens such as HCV or SARS-CoV-2.
Published in
A Comparative Study of Human Pluripotent Stem Cell-Derived Macrophages in Modeling Viral Infections
Zhang Y, Qiu H, Duan F et al. · Viruses 2024 · PMID 38675895 · doi:10.3390/v16040552
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Also filed as BioProject PRJNA1067602 and SRA study SRP485221. Searching any of these in the dataset finder brings you back here.

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