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Integrated Multi-Omics Profiling Reveals Neutrophil Extracellular Traps Promote Aortic Dissection

GSE254132 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/01 Platform GPL24676
Summary
Adverse aortic remodeling increases the risk of aorta-related adverse events (AAEs) after thoracic endovascular aortic repair (TEVAR) and affects the overall prognosis of aortic dissection (AD). It is imperative to delve into the exploration of prognostic indicators to We performed single-cell transcriptomic and proteomic profiling of aortic lesions and peripheral blood samples, respectively, from patients with AD and healthy subjects. We then integrated single-cell RNA to identify phenotype-relevant subpopulations.
Published in
Integrated multi-omics profiling reveals neutrophil extracellular traps potentiate Aortic dissection progression
Zhao YF, Zuo ZA, Li ZY et al. · Nature communications 2024 · PMID 39737994 · doi:10.1038/s41467-024-55038-8
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Also filed as BioProject PRJNA1068608 and SRA study SRP485753. Searching any of these in the dataset finder brings you back here.

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