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Failing heart-specific cardiac fibroblasts induce heart failure via c-Myc

GSE254172 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/07/17 Platform GPL24247
Summary
Heart failure (HF) is a global concern, marked by limited therapeutic options. While existing studies primarily focus on cardiomyocytes, there is a notable absence of drugs targeting noncardiomyocytes for HF. We focused on cardiac fibroblasts (CFs), utilising single-cell RNA-sequencing analysis. The analysis of murine hearts revealed one subcluster exclusive to the HF stage. The transcription factor c-Myc is specifically expressed in heart failure-specific fibroblasts (HF-Fibro). Cardiac fibroblast-specific deletion of c-Myc ameliorates pressure overload-induced cardiac dysfunction without affecting fibrosis. To elucidate the molecular function of c-Myc in HF-Fibro, transcriptome analysis by RNA-seq was conducted, in vivo.
Published in
Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC-CXCL1-CXCR2 axis
Komuro J, Hashimoto H, Katsuki T et al. · Nature cardiovascular research 2025 · PMID 40931092 · doi:10.1038/s44161-025-00698-y
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Also filed as BioProject PRJNA1068679 and SRA study SRP485773. Searching any of these in the dataset finder brings you back here.

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