Epigenetic regulation of chromosomal instability by EZH2 methyltransferase [CUT&RUN]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 3 × H3K27me3_GFPpos_EPZ_Day7 vs 3 × H3K27me3_GFPneg_EPZ_Day7 vs 2 × H3K27me3_GFPpos_Untreated_Day7 vs 2 × H3K27me3_GFPneg_Untreated_Day7Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Epigenetic Regulation of Chromosomal Instability by EZH2 MethyltransferaseCancer discovery · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE254324_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1069752 and SRA study SRP486154. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8037745 H3K27me3_GFPpos_Untreated_Day7
- GSM8037746 H3K27me3_GFPpos_Untreated_Day7 replicate 2 H3K27me3_GFPpos_Untreat…
- GSM8037747 H3K27me3_GFPpos_Untreated_Day7 replicate 3 H3K27me3_GFPpos_Untreat…
- GSM8037748 H3K27me3_GFPpos_EPZ_Day7
- GSM8037749 H3K27me3_GFPpos_EPZ_Day7 replicate 2 H3K27me3_GFPpos_EPZ_Day7
- GSM8037750 H3K27me3_GFPpos_EPZ_Day7 replicate 3 H3K27me3_GFPpos_EPZ_Day7
- GSM8037751 H3K27me3_GFPpos_EPZ_Day7 replicate 4 H3K27me3_GFPpos_EPZ_Day7
- GSM8037752 H3K27me3_GFPneg_Untreated_Day7
- GSM8037753 H3K27me3_GFPneg_Untreated_Day7 replicate 2 H3K27me3_GFPneg_Untreat…
- GSM8037754 H3K27me3_GFPneg_Untreated_Day7 replicate 3 H3K27me3_GFPneg_Untreat…
- GSM8037755 H3K27me3_GFPneg_EPZ_Day7
- GSM8037756 H3K27me3_GFPneg_EPZ_Day7 replicate 2 H3K27me3_GFPneg_EPZ_Day7
- GSM8037757 H3K27me3_GFPneg_EPZ_Day7 replicate 3 H3K27me3_GFPneg_EPZ_Day7
- GSM8037758 H3K27me3_GFPneg_EPZ_Day7 replicate 4 H3K27me3_GFPneg_EPZ_Day7
- GSE289642 Noncanonical PRC2 chromatin association reveals a key role of EZHIP in intergenerational epigenetic memory transition [ChIP-Seq, Cut & Run] 107 samples shares cut, run, epigenetic
- GSE313359 Hippocampal estrogen levels, receptor types and epigenetics contribute to sex-specific memory-vulnerabilities to concurrent acute stresses [Cut & Run] 45 samples shares cut, run, epigenetic
- GSE298002 Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [CUT&Run] 38 samples shares cut, run, epigenetic
- GSE253201 Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis [CUT&RUN] 18 samples shares cut, run
- GSE279279 KDM6A facilitates Xist upregulation at the onset of X inactivation [CUT&Run] 14 samples shares cut, run
- GSE303384 Mechanism of maintenance and establishment of repression by the Mtg16 tumor suppressor [CUT&RUN, ChIP-Seq] 92 samples shares cut, run
- GSE306261 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [CUT&RUN] 50 samples shares cut, run
- GSE292333 H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes [CATCH-seq and CUT&RUN] 44 samples shares cut, run
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.