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Single-cell RNA-sequencing of whole blood from human burn patients

GSE254329 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/05/01 Platform GPL24676
Summary
To develop effective therapeutic interventions that prevent scar formation and encourage regeneration of healthy skin, we need to better understand the cellular and molecular process that are engaged during the wound healing process in humans. However, our cellular and molecular understanding of how humans heal deep dermal wounds remains limited. Our recent work using different animal models of skin wound healing has identified the acute wound healing immune response as a key determinant of terminal fibrotic outcomes. Here, our goal is to compare the immune response during human wound healing to datasets we have generated from large animal models that are capable of scarless healing, in order to determine how to most appropriately modify the process in humans to improve outcomes (and mitigate scar).
Published in
Immature Neutrophil Programs Associate with Burn Mortality and Extend Across Critical Illnesses
Sinha S, Mandujano-Tinoco EA, Kutluberk E et al. · Journal of burn care & research : official publication of the American Burn Association 2026 · PMID 42053371 · doi:10.1093/jbcr/irag067
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Direct links to NCBI, no account and no request form: the whole study as GSE254329_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1069749 and SRA study SRP486160. Searching any of these in the dataset finder brings you back here.

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