In the aftermath of stroke or myocardial infarction, neutrophil extracellular traps disrupt systemic immunoglobulin production
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE254410_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1070340 and SRA study SRP486645. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8041761 PP_B_sham_1 [RNA_S5219Nr1]
- GSM8041762 PP_B_sham_2 [RNA_S5219Nr2]
- GSM8041763 PP_B_sham_3 [RNA_S5219Nr3]
- GSM8041764 PP_B_sham_4 [RNA_S5219Nr4]
- GSM8041765 PP_B_sham_5 [RNA_S5219Nr5]
- GSM8041766 PP_B_sham_6 [RNA_S5219Nr6]
- GSM8041767 PP_B_brain_injury_1 [RNA_S5219Nr7]
- GSM8041768 PP_B_brain_injury_2 [RNA_S5219Nr8]
- GSM8041769 PP_B_brain_injury_3 [RNA_S5219Nr9]
- GSM8041770 PP_B_brain_injury_4 [RNA_S5219Nr10]
- GSM8041771 PP_B_brain_injury_5 [RNA_S5219Nr11]
- GSM8041772 PP_B_brain_injury_6 [RNA_S5219Nr12]
- GSE291292 Navarixin alleviates cardiac remodeling after myocardial infarction by decreasing neutrophil infiltration and the inflammatory response 10 samples shares myocardial, infarction, neutrophil
- GSE295428 Spaceflight induces systemic effects on extracellular matrix and immune system in different age-stages 229 samples shares extracellular, systemic
- GSE330865 Multiorgan transcriptomics and circulating extracellular vesicle profiling reveal age-dependent systemic vulnerability to isoflurane anesthesia and surgery 120 samples shares extracellular, systemic
- GSE252027 Temporal co-regulation of microRNA arms among cell types after myocardial infarction [RNA-Seq] 96 samples shares myocardial, infarction
- GSE306097 Distinct immunometabolic signatures of type 1 versus type 2 diabetes in a murine model of myocardial infarction 55 samples shares myocardial, infarction
- GSE307187 Gene expression following myocardial infarction in mice with Stimulated by retinoic acid gene 6 (Stra6) germline deletion, Vitamin A deficiency, and the combination of both 46 samples shares myocardial, infarction
- GSE282766 VEGFA Stop-gained Variant Deteriorates Cardiac Remodeling in Myocardial Infarction [RNA-seq] 43 samples shares myocardial, infarction
- GSE255933 Empagliflozin in acute myocardial infarction reduces no-reflow and preserves cardiac function by preventing endothelial damage 38 samples shares myocardial, infarction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.