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Reduced DNAJB1 expression contributes to aging insubstantia nigra: insights from single-nuclei RNA seq

GSE254518 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/26 Platform GPL24247
Summary
In this study, we established a comprehensive single-nucleus transcriptomic atlas of human SN across lifespan, from adolescents to centenarians. Notably, we discovered that the protein folding pathway was commonly downregulated among different SN cell types across aging. With orthogonal expression and functional validations, we demonstrated that a decrease in Dnajb1 expression results in reduced potassium ion channels, resulting in elevated neuronal excitability, cellular senescence, reactive astrocytes, ultimately impaired motor balance, and behavioral outputs phenotyping anxiety and depression.
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Also filed as BioProject PRJNA1070699 and SRA study SRP486595. Searching any of these in the dataset finder brings you back here.

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