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The effect of TRAF6 loss on the gene expression profiles in leukemia cells I

GSE254614 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/05/15 Platform GPL16791
Summary
Although altered TRAF6 expression is observed in human acute myeloid leukemia (AML), its role in the AML pathogenesis remains elusive. In this study, we showed that the loss of TRAF6 in AML cells significantly impairs leukemic function in vitro and in vivo, indicating its functional importance in AML subsets. Loss of TRAF6 induces metabolic alterations, such as changes in glycolysis as well as impaired mitochondrial membrane potential and respiratory capacity. The restoration of growth capacity and metabolic activity in leukemic cells with TRAF6 loss, achieved through either forced expression of OGT or pharmacological inhibition of O-GlcNAcase (OGA) that removes O-GlcNAc, indicates the significant role of O-GlcNAc modification in the TRAF6-related cellular and metabolic dynamics. Our findings highlight the oncogenic function of TRAF6 in leukemia and illuminate the novel TRAF6/OGT/O-GlcNAc axis as a potential regulator of metabolic reprogramming in leukemogenesis.
Published in
Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression
Matsui S, Ri C, Bolanos LC et al. · Leukemia 2024 · PMID 38609495 · doi:10.1038/s41375-024-02245-3
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Also filed as BioProject PRJNA1071140 and SRA study SRP486915. Searching any of these in the dataset finder brings you back here.

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