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Breast cancer cell/adipocyte crosstalk and Tamoxifen Resistance: a potential role for IGF-1/TXNIP axis

GSE254882 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/16 Platform GPL18573
Summary
Although endocrine therapy (ET) has improved the outcomes of Estrogen Receptor (ER) α-positive breast cancer (BC) patients, resistance to these treatments remains a major challenge. Evidence proved that a reduced response to ET is tightly dependent on the surrounding microenvironment and on the host characteristics. Indeed, several studies have highlighted that obesity, in addition to promote BC development and progression, represents a heavyweight player driving ET resistance. Here, we evaluated the influence of adipocytes and their secretome on the efficacy of ET. Our findings bring insights on adipocytes and mammary cancer cell crosstalk during endocrine therapy, suggesting the possibility to target IGF-1/TXNIP axis to block this harmful connection, especially in obesity settings.
Published in
Adipocyte/Tumor cell crosstalk via IGF-1/TXNIP axis promotes malignancy and endocrine resistance in breast cancer
Caruso A, Accattatis FM, Giordano C et al. · Cell communication and signaling : CCS 2025 · PMID 40462107 · doi:10.1186/s12964-025-02262-4
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Direct links to NCBI, no account and no request form: the whole study as GSE254882_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1072137 and SRA study SRP487560. Searching any of these in the dataset finder brings you back here.

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