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Hair follicles modulate skin barrier function

GSE254889 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2024/05/20 Platform GPL24247
Summary
We generated KA mutant mice (Krt14-CreERT + ABCA12-flox/flox) and controls (ABCA12-flox/flox) that enabled us to assess the effects of deleting a critical barrier gene, ABCA12, in the skin epidermis following tamoxifen treatment. These studies identified numerous differentially expressed genes (DEGs) upon barrier disruption/ABCA12 deletion, including compensatory upregulation of genes involved with epidermal differentiation and barrier function. Overall, this data-set provides a global view of molecular changes that occur in adult mouse skin following barrier perturbation.
Published in
Hair follicles modulate skin barrier function
Ford NC, Benedeck RE, Mattoon MT et al. · Cell reports 2024 · PMID 38941190 · doi:10.1016/j.celrep.2024.114347
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Direct links to NCBI, no account and no request form: the whole study as GSE254889_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1072231 and SRA study SRP487647. Searching any of these in the dataset finder brings you back here.

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