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USP2 inhibition overcomes CD47-mediated phagocytosis suppression and enhances anti-tumor immunity.

GSE254966 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2025/04/03 Platform GPL24247
Summary
USP2 inhibition by ML364 treatment significantlly suppressed tumor growth. We aim to investigate the impact of ML364 treatment on the immune microenvironment of tumor-bearing mice by single-cell sequencing.
Published in
USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity
Dai P, Sun Y, Huang Z et al. · Nature communications 2025 · PMID 40379682 · doi:10.1038/s41467-025-59621-5
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Also filed as BioProject PRJNA1072155 and SRA study SRP487563. Searching any of these in the dataset finder brings you back here.

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