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Potent Suppression of Heme-Induced Ferroptosis in Cardiomyocytes Enhances Cardiac Function Following Myocardial Infarction/Reperfusion Injury

GSE285626 Mus musculus (mouse) RNA-seq (gene expression) 18 samples Submitted 2025/12/31 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 18 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Summary (written by the submitters)
Myocardial ischemia-reperfusion injury (MIRI) significantly worsens outcomes following myocardial infarction, primarily due to microvascular obstruction-induced myocardial hemorrhage in deeper regions. This hemorrhage leads to heme accumulation and triggers ferroptosis, a crucial pathological mechanism recently identified. Existing pharmacological treatments are ineffective and fail to reach the infarct core.
Read the full summary ↓
To address this issue, we developed DecAS-PC@NM, a novel heme-responsive biomimetic vesicle loaded with decursin, an anti-ferroptosis herbal monomer. The vesicle is composed of synthetic phosphatidylcholines derived from artemisinin and thioether, engineered to disassemble and release decursin in response to heme-triggered reactive oxygen species that oxidize the thioether within the phospholipid bilayer. Incorporation of neutrophil membranes enhances targeting to the lesion. In vitro and in vivo studies demonstrated that DecAS-PC@NM effectively accumulates in the infarct core, counteracts ferroptosis and inflammatory responses, and significantly improves cardiac function. This targeted approach offers a promising therapeutic strategy for MIRI by specifically addressing heme accumulation and ferroptosis.
This dataset
Open GSE285626 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285626_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1204981 and SRA study SRP554723. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗
Study design
18 samples, each with a distinct title — no replicated groups

Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.

How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.