GEO series
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs [BulkRNA]
GSE255100
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/02/07
GPL24247
Summary
Through a multi-omics approach, we discovered that metformin acts by enhancing the methylation potential in Dnmt3aR878H/+ cells and reversing their aberrant DNA CpG methylation and histone H3K27 trimethylation (H3K27me3) profiles.
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Paper (PMID 40240595) ↗
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