Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs
DNA methylation · mouse · 43 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Mus musculus (mouse)
- Samples
- 43 samples: 41 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Metformin reduces the competitive advantage of Dnmt3a(R878H) HSPCsNature · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255101_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1073514 and SRA study SRP487427. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 43 sample titles: 41 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8058176 vehicle replicate 1
- GSM8058177 vehicle replicate 1.1
- GSM8058178 vehicle replicate 2
- GSM8058179 vehicle replicate 2.1
- GSM8058180 metformin replicate 1
- GSM8058181 metformin replicate 1.1
- GSM8058182 metformin replicate 2
- GSM8058183 metformin replicate 2.1
- GSM8064127 WT VEH-1 replicate
- GSM8064128 WT VEH-2 replicate
- GSM8064129 WT MET-1 replicate
- GSM8064132 RH VEH-2 replicate
- GSM8064133 RH MET-1 replicate
- GSM8064134 RH MET-2 replicate
- GSM8074588 WT VEH-1 replicate ChIP
- GSM8074589 WT VEH-2 replicate ChIP
- GSM8074590 WT MET-1 replicate ChIP
- GSM8074591 WT MET-2 replicate ChIP
- GSM8074592 RH VEH-1 replicate ChIP
- GSM8074593 RH VEH-2 replicate ChIP
- GSM8074594 RH MET-1 replicate ChIP
- GSM8074595 RH MET-2 replicate ChIP
- GSM8074596 Input ChIP
- GSM8080144 WT RRBS VEH-2 replicate
- GSM8080145 WT RRBS VEH-3 replicate
- GSM8080146 WT RRBS VEH-4 replicate
- GSM8080147 WT RRBS MET-1 replicate
- GSM8080148 WT RRBS MET-2 replicate
- GSM8080149 WT RRBS MET-3 replicate
- GSM8080150 WT RRBS MET-4 replicate
- GSM8080151 RH RRBS VEH-1 replicate
- GSM8080152 RH RRBS VEH-2 replicate
- GSM8080153 RH RRBS VEH-3 replicate
- GSM8080154 RH RRBS VEH-4 replicate
- GSM8080155 RH RRBS MET-1 replicate
- GSM8080156 RH RRBS MET-2 replicate
- GSM8080157 RH RRBS MET-3 replicate
- GSM8812315 WT VEH-4 replicate
- GSM8812316 WT MET-3 replicate
- GSM8812317 WT MET-4 replicate
+ 3 more — browse all 43 samples with per-sample file links →
- GSE255100 Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs [BulkRNA] 12 samples shares competitive, dnmt3ar878h, metformin, advantage, reduces, hspcs
- GSE255550 Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs [ChIP-Seq] 9 samples shares competitive, dnmt3ar878h, metformin, advantage, reduces, hspcs
- GSE254822 Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs [CITE-Seq] 8 samples shares competitive, dnmt3ar878h, metformin, advantage, reduces, hspcs
- GSE264041 TET2 Deficiency Increases the Competitive Advantage of Hematopoietic Stem Cells through Upregulation of Thrombopoietin Receptor Signaling 28 samples shares competitive, advantage
- GSE319230 Metformin reduces RAN proteins and rescues molecular and behavioral phenotypes in SCA8 mice 12 samples shares metformin, reduces
- GSE237750 Transcriptomic profiling across 20 CC-RIX genetic backgrounds with and without high-fat high-sugar (HFHS) diet, and with and without metformin 2113 samples shares metformin
- GSE237737 Transcriptomic profiling across 20 CC-RIX genetic backgrounds with and without high-fat high-sugar (HFHS) diet, and with and without metformin [adipose] 705 samples shares metformin
- GSE237743 Transcriptomic profiling across 20 CC-RIX genetic backgrounds with and without high-fat high-sugar (HFHS) diet, and with and without metformin [liver] 705 samples shares metformin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.