Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice
Single-cell RNA-seq · mouse · 18 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 5 × e12_to_e12 vs 5 × e12_to_e16 vs 4 × e16_to_e16 vs 4 × e16_to_e12Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Temporal control of progenitor competence shapes maturation in GABAergic neuron development in miceNature neuroscience · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255103_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1073524 and SRA study SRP488243. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 4 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8064141 e12_to_e12_replicate1 e12_to_e12
- GSM8064142 e12_to_e12_replicate2 e12_to_e12
- GSM8064143 e12_to_e12_replicate3 e12_to_e12
- GSM8064144 e12_to_e12_replicate4 e12_to_e12
- GSM8064145 e12_to_e12_replicate5 e12_to_e12
- GSM8064146 e12_to_e16_replicate1 e12_to_e16
- GSM8064147 e12_to_e16_replicate2 e12_to_e16
- GSM8064148 e12_to_e16_replicate3 e12_to_e16
- GSM8064149 e12_to_e16_replicate4 e12_to_e16
- GSM8064150 e12_to_e16_replicate5 e12_to_e16
- GSM8064151 e16_to_e16_replicate1 e16_to_e16
- GSM8064152 e16_to_e16_replicate2 e16_to_e16
- GSM8064153 e16_to_e16_replicate3 e16_to_e16
- GSM8064154 e16_to_e16_replicate4 e16_to_e16
- GSM8064155 e16_to_e12_replicate1 e16_to_e12
- GSM8064156 e16_to_e12_replicate2 e16_to_e12
- GSM8064157 e16_to_e12_replicate3 e16_to_e12
- GSM8064158 e16_to_e12_replicate4 e16_to_e12
- GSE327470 Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System 292 samples shares progenitor, temporal
- GSE327468 Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System – MADM-CloneSeq 287 samples shares progenitor, temporal
- GSE272496 Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure 38 samples shares gabaergic, control
- GSE325932 Disease-associated microRNA, miR-9-2, is required for the timing of retinal progenitor cell competence and the maintenance of Müller glial identity 32 samples shares progenitor, competence
- GSE240857 Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner[RNA-Seq] 29 samples shares maturation, neuron
- GSE269184 Dynamic expression of Erg controls fetal-to-adult maturation of the hematopoietic system [RNA-seq] 12 samples shares maturation, control
- GSE293592 Maternal immune activation delays DNA methylation and physiological maturation of cortical excitatory neurons 106 samples shares maturation, neuron
- GSE205438 RNA splicing controls organ-wide maturation of postnatal heart in mice 88 samples shares maturation, control
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.