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Genome-wide map of TRIM33, CDK9 and S2 Pol II binding sites in common dendritic cell progenitors

GSE255136 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/06/01 Platform GPL21273
Summary
Transcriptional control of dendritic cell (DC) development has not been fully understood. TRIM33, a transcription co-factor was found to be crucial for transcription regulation during the development of DCs. Genome wide binding site analysis with CUT&Tag revealed co-localization of TRIM33 with CDK9 and Serine 2 phosphorylated RNA polymerase (S2 Pol II) in the common dendritic cell progenitors (CDPs).
Published in
TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription
Shen X, Li X, Wu T et al. · Cellular & molecular immunology 2024 · PMID 38822080 · doi:10.1038/s41423-024-01179-1
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Also filed as BioProject PRJNA1073583 and SRA study SRP488344. Searching any of these in the dataset finder brings you back here.

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