GEO series
mRNAseq profiles of gastrocnemius of 24-day-old Nnt-wt male mouse exposed to hypoxia
GSE255522
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2025/04/08
GPL24247
Summary
Gene expression profiles from gastrocnemius of fasted Nnt-wt male mice exposed to hypoxia (12%O2) or normoxia for 6 hours (n=12 per group). Result showed that the FOXO1 was the main transcription factor regulated by hypoxia. FOXO1 activation induces regulation of gene expression related to protein degradation (ubequitin-proteasome system) (atrophy), autophagy and apoptosis inhibition.
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Paper (PMID 40094441) ↗
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