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In vivo dendritic cell reprogramming for cancer immunotherapy [organoid scRNA]

GSE255536 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/09/05 Platform GPL24676
Summary
Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor microenvironment. Here, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, IRF8, and BATF3, which enabled them to present antigens as type 1 conventional dendritic cells. Reprogrammed tumor cells remodeled their tumor microenvironment, recruited, and expanded polyclonal cytotoxic T cells, induced tumor regressions, and established long-term systemic immunity in multiple mouse melanoma models. In human tumor spheroids and xenografts, reprogramming to immunogenic dendritic-like cells progressed independently of immunosuppression, which usually limits immunotherapy. Our study paves the way for human clinical trials of in vivo immune cell reprogramming for cancer immunotherapy.
Published in
In vivo dendritic cell reprogramming for cancer immunotherapy
Ascic E, Åkerström F, Sreekumar Nair M et al. · Science (New York, N.Y.) 2024 · PMID 39236156 · doi:10.1126/science.adn9083
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Also filed as BioProject PRJNA1075314 and SRA study SRP489238. Searching any of these in the dataset finder brings you back here.

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