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Impact of Nfat5 on normoxia- and hypoxia-exposed mouse lung endothelial cells

GSE255681 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/08/08 Platform GPL24247
Summary
Chronic hypoxia causes detrimental structural alterations in the lung, which are partially dependent on stress responses of the endothelium. In this context, we revealed that hypoxia-exposed murine lung endothelial cells (MLEC) activate nuclear factor of activated T-cells 5 (NFAT5/TonEBP) - a transcription factor that adjusts the cellular transcriptome to cope with multiple environmental stressors. Here, we studied the impact of NFAT5 on hypoxia-induced gene expression in MLEC by comparing the transcriptome of control and Nfat5-deficient MLEC, which were isolated from mouse lungs after exposure to normoxia and hypoxia for 7 days and processed for scRNA seq.
Published in
Nuclear factor of activated T-cells 5 is indispensable for a balanced adaptive transcriptional response of lung endothelial cells to hypoxia
Laban H, Siegmund S, Schlereth K et al. · Cardiovascular research 2024 · PMID 39107245 · doi:10.1093/cvr/cvae151
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Also filed as BioProject PRJNA1076150 and SRA study SRP489611. Searching any of these in the dataset finder brings you back here.

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