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The Effects of Complement in a Chronic Murine Model of Inflammatory Erosive Arthritis and Pulmonary Vascular Disease

GSE255755 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/31 Platform GPL24247
Summary
Dysfunction of the complement pathway contributes to diseases such rheumatoid arthritis (RA) and pulmonary hypertension (PH). Here we aim to determine whether complement deficiency has a protective effect on joint and lung disease using the tumor necrosis factor-transgenic (TNF-Tg) mouse model with constitutive human TNF-ɑ expression characterized by spontaneous onset of inflammatory-erosive arthritis and PH.
Published in
Mixed effects of complement in a chronic murine model of inflammatory erosive arthritis and pulmonary vascular disease
Chen KL, Duemmel S, Christof M et al. · PloS one 2026 · PMID 41642804 · doi:10.1371/journal.pone.0340677
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Also filed as BioProject PRJNA1076463 and SRA study SRP489714. Searching any of these in the dataset finder brings you back here.

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