← BioTransfer GEO Dataset Finder
GEO series

SUMOylation of zebrafish transcription factor Zbtb21 affects its transcription activity [RNA-Seq]

GSE255803 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/06 Platform GPL24676
Summary
Phylogenetically conserved lysines 419 and 845 of zebrafish Zbtb21 protein can be conjugated with SUMO molecules. SUMOylation does not affect the subcellular localization and protein stability of Zbtb21, as well as the interaction with Zbtb14 or Zbtb21. Nevertheless, luciferase reporter assays revealed that Zbtb21 is a dual-function transcription factor which exerts activation or repression effect on different promoters, and SUMOylation can modulate the transcriptional activity of Zbtb21 in regulating downstream target genes. Hence, Zbtb21 is identified as a novel substrate of SUMOylation, which would be important for its function.
Published in
SUMOylation of zebrafish transcription factor Zbtb21 affects its transcription activity
Fang Z, Deng Y, Wang H et al. · PeerJ 2024 · PMID 38666079 · doi:10.7717/peerj.17234
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE255803_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1076554 and SRA study SRP489776. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.