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Expression profiles in pancreatic islets from Wfs1-deficient mice

GSE255872 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/01/01 Platform GPL21626
Summary
Wolfram syndrome is a genetic disorder characterized by insulin-dependent diabetes mellitus due to mutations in the WFS1 gene. The Wfs1-deficient mice exhibit selective β-cell loss and impaired insulin secretion. This phenotype is believed to be associated with an augmentation of ER stress, although the underlying mechanisms remain unknown. To investigate the molecular basis of β-cell failure resulting from Wfs1 deficiency, we performed gene expression profiling analysis using data obtained from RNA-seq of Wfs1KO and WT islets.
Published in
β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome
Amo-Shiinoki K, Tanabe K, Nishimura W et al. · Science translational medicine 2025 · PMID 39970233 · doi:10.1126/scitranslmed.adp2332
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Also filed as BioProject PRJNA1076885 and SRA study SRP489908. Searching any of these in the dataset finder brings you back here.

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