GEO series
Gene expression of alveolar macrophage in mice with AT2 cell-specific Cpt1a deletion
GSE255949
Mus musculus
Expression profiling by high throughput sequencing
11 samples
2024/07/05
GPL24247
Summary
Carnitine palmitoyltransferase 1a (CPT1a) is the key regulator of mitochondrial long-chain fatty acid beta-oxidation (LCFAO). However, the functional significance of AT2 cell-specific LCFAO at baseline and during acute lung injury (ALI) is not fully understood. In this study, Murine models of AT2 cell-specific Cpt1a deletion were generated for investigating the role of CPT1a in regulating AT2 cell function and the severity of lipopolysaccharide-induced murine ALI models.
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Paper (PMID 39174557) ↗
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