GEO series
Zalfermin and semaglutide have beneficial effects liver histology and fibrotic gene in a murine model of NASH
GSE256063
Mus musculus
Expression profiling by high throughput sequencing
56 samples
2025/02/01
GPL19057
Summary
The potential clinical benefits of FGF21 analogues for the treatment of NASH has evolved significantly within the last years. However, despite clinical meaningful effect on NASH resolution and fibrosis the body weight loss in humans have been less impressive. Thus, a combination of an FGF21 analogue with a GLP-1 receptor agonist may add additional benefit to the treatment of NASH due to complimentary mode of action compared to stand alone therapies
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Paper (PMID 41150667) ↗
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