← BioTransfer GEO Dataset Finder
GEO series

RNA-seq in HUVECs upon DDX24 knockdown

GSE256144 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/20 Platform GPL21290
Summary
DEAD-box (DDX) RNA helicases play crucial roles in gene regulation by interacting with RNAs and influencing RNA fate and function. Previously, we have associated DDX24 with vascular development, but its precise role in RNA metabolism remains unclear. In this study, we demonstrate that DDX24 modulated endothelial cell functions by binding to and regulating mRNAs crucial for vascular morphogenesis and angiogenesis. These results establish a link between DDX24-dependent regulation of mRNA stability and endothelial cell function, providing novel therapeutic targets for angiogenesis.
Published in
DDX24 modulates angiogenesis by promoting CCR4-NOT complex-dependent mRNA decay
He S, Li B, Chen F et al. · Nucleic acids research 2026 · PMID 41728947 · doi:10.1093/nar/gkag130
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE256144_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1078325 and SRA study SRP490481. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.