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IL-17 signaling pathway and NMDAR1 antibodies shape NMDAR encephalitis

GSE256148 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2026/04/08 Platform GPL29480
Summary
Human forebrain organoids (hFOs, day 110) derived from U2F iPS cell line were exposed with or without 10 μg/mL anti-NMDAR1 antibody for 24 hours. Organoids were then randomly selected for RNA sequencing (RNA-seq). By performing RNA-seq analysis, we showed that anti-NMDAR1 antibody exposure in hFOs downregulated expression of genes enriched with multiple neuronal functions including the glutamatergic synapse.These downregulated genes were also enriched with neuropsychiatric disorder-related genes.
Published in
The anti-NMDAR1 antibodies and IL-17 signaling pathway shape NMDAR encephalitis
Xu Z, Yan H, Wang B et al. · Molecular psychiatry 2026 · PMID 41436585 · doi:10.1038/s41380-025-03434-x
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Also filed as BioProject PRJNA1078331 and SRA study SRP490586. Searching any of these in the dataset finder brings you back here.

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