GEO series
The role of Rack1 in microglia in AD
GSE256191
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2024/06/30
GPL24247
Summary
We found that Rack1 increased in microglia in AD mouse model. Conditional knockout of Rack1 in microglia reduced Aβ aggregation, alleviated neuroinflammation, and rescued cognitive impairments in AD mouse model. Mechanism investigation revealed that knockout of Rack1 in microglia decreased microglial numbers but increased astrocytic numbers and phagocytic activities via IGF1-IGF1R signaling.
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