Neutral sphingomyelinase 2 inhibition alters inflammatory gene expression signatures in the brain of mice infected with West Nile virus
RNA-seq (gene expression) · mouse · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 27 samples: 12 × Vehicle, brain, 7 dpi, vs 11 × DPTIP, brain, 7 dpi, vs 4 × Mock, brain, 7 dpi,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Neutral sphingomyelinase 2 inhibition alters inflammatory gene expression signatures in the brain of mice infected with West Nile virusInternational immunopharmacology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE256333_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1079206 and SRA study SRP490966. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 27 samples.
How we read this: 3 replicated groups read from 27 sample titles; they account for 27 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8093838 Vehicle, brain, 7 dpi, R1 Vehicle, brain, 7 dpi,
- GSM8093839 Vehicle, brain, 7 dpi, R2 Vehicle, brain, 7 dpi,
- GSM8093840 Vehicle, brain, 7 dpi, R3 Vehicle, brain, 7 dpi,
- GSM8093841 Vehicle, brain, 7 dpi, R4 Vehicle, brain, 7 dpi,
- GSM8093842 Vehicle, brain, 7 dpi, R5 Vehicle, brain, 7 dpi,
- GSM8093843 Vehicle, brain, 7 dpi, R6 Vehicle, brain, 7 dpi,
- GSM8093844 Vehicle, brain, 7 dpi, R7 Vehicle, brain, 7 dpi,
- GSM8093845 Vehicle, brain, 7 dpi, R8 Vehicle, brain, 7 dpi,
- GSM8093846 Vehicle, brain, 7 dpi, R9 Vehicle, brain, 7 dpi,
- GSM8093847 Vehicle, brain, 7 dpi, R10 Vehicle, brain, 7 dpi,
- GSM8093848 Vehicle, brain, 7 dpi, R11 Vehicle, brain, 7 dpi,
- GSM8093849 Vehicle, brain, 7 dpi, R12 Vehicle, brain, 7 dpi,
- GSM8093850 Mock, brain, 7 dpi, R1 Mock, brain, 7 dpi,
- GSM8093851 Mock, brain, 7 dpi, R2 Mock, brain, 7 dpi,
- GSM8093852 Mock, brain, 7 dpi, R3 Mock, brain, 7 dpi,
- GSM8093853 Mock, brain, 7 dpi, R4 Mock, brain, 7 dpi,
- GSM8093854 DPTIP, brain, 7 dpi, R1 DPTIP, brain, 7 dpi,
- GSM8093855 DPTIP, brain, 7 dpi, R3 DPTIP, brain, 7 dpi,
- GSM8093856 DPTIP, brain, 7 dpi, R4 DPTIP, brain, 7 dpi,
- GSM8093857 DPTIP, brain, 7 dpi, R5 DPTIP, brain, 7 dpi,
- GSM8093858 DPTIP, brain, 7 dpi, R6 DPTIP, brain, 7 dpi,
- GSM8093859 DPTIP, brain, 7 dpi, R7 DPTIP, brain, 7 dpi,
- GSM8093860 DPTIP, brain, 7 dpi, R8 DPTIP, brain, 7 dpi,
- GSM8093861 DPTIP, brain, 7 dpi, R9 DPTIP, brain, 7 dpi,
- GSM8093862 DPTIP, brain, 7 dpi, R10 DPTIP, brain, 7 dpi,
- GSM8093863 DPTIP, brain, 7 dpi, R11 DPTIP, brain, 7 dpi,
- GSM8093864 DPTIP, brain, 7 dpi, R12 DPTIP, brain, 7 dpi,
- GSE300534 Brain Mecp2 Genetic Dosage and Gene Therapy Shape Multi-omics Signatures and Biomarkers in Rett Syndrome [1] 137 samples shares signatures, brain
- GSE300536 Brain Mecp2 Genetic Dosage and Gene Therapy Shape Multi-omics Signatures and Biomarkers in Rett Syndrome [2] 137 samples shares signatures, brain
- GSE243373 Genome-wide 5mC and 5hmC patterns determine unique transcriptional signatures,regulators and exon inclusion of neural cell types in mouse brain [RNA-Seq] 15 samples shares signatures, brain
- GSE236963 Spatial Transcriptomics of Meningeal Inflammation Reveals Variable Penetrance of Inflammatory Gene Signatures into Adjacent Brain Parenchyma 11 samples shares signatures, brain
- GSE319820 Efficient in vivo pharmacological inhibition of ∆FOSB with YL-0441 in brain 38 samples shares inhibition, brain
- GSE253570 Molecular signatures and spatial distribution of disease-associated cellular populations in early-onset Alzheimer's disease mouse brain 12 samples shares signatures, brain
- GSE263892 Single-cell analysis reveals Mycobacterium tuberculosis ESX-1-mediated accumulation of permissive macrophages in infected mouse lungs 6078 samples shares infected
- GSE255212 Transcriptomic Signatures of WNT-Driven Pathways and Granulosa Cell-Oocyte Interaction during Primordial Follicle Activation 762 samples shares signatures
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.