GEO series
Obesity-disrupted H3K4me3 in hematopoietic stem progentior cells in mice
GSE256500
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
14 samples
2024/03/07
GPL19057
Summary
Obesity alters long-term functions of hematopoietic stem cells (HSPCs), which are associated with myelopoitic bias and maladapted pro-inflammatory phenotype. H3K4me3 histone modification is generally considered an activating histone marks and is also liked with epigenetic programming for trained immunity. We aim to identify how obesity in mice alter H3K4me3 marks in HSPCs and study its impact on HSPC functions in vitro and in vivo.
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Paper (PMID 40795290) ↗
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