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Effect of GSK3 inhibition on the transcriptional signature of human monocytes

GSE256538 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/04/16 Platform GPL23227
Summary
We explored the molecular impact of blocking GSK3 on the gene expression profile in human monocytes. GSK3 inhibition by CHIR-99021 redirected monocytes towards acquiring an anti-inflammatory gene profile similar to M-CSF-primed monocyte-derived macrophages.
Published in
Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation
Ríos I, Herrero C, Torres-Torresano M et al. · eLife 2025 · PMID 40365863 · doi:10.7554/eLife.102659
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Also filed as BioProject PRJNA1080033 and SRA study SRP491513. Searching any of these in the dataset finder brings you back here.

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