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Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression in an rs5918762 allele-dependent manner (ONT long read sequencing)

GSE259334 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/09/26 Platform GPL26167
Summary
The Cdc2-like kinase (CLK)-family is a regulator of the splicing process. Here, we report the effect of Lorecivivint (SM04690), a CLK/DYRK inhibitor, on alternative splicing in the prostate cancer cell line 22Rv1. Lorecivivint treatment lead to impaired growth and disruption of several oncogenic pathways, including the androgen response, MYC, and Wnt/β-catenin hallmark pathways. Taken together, this data shows that alternative splicing is a pivotal process in prostate cancer and is suitable to be targeted.
Published in
Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression
Van Goubergen J, Peřina M, Handle F et al. · Molecular oncology 2025 · PMID 39258426 · doi:10.1002/1878-0261.13728
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Also filed as BioProject PRJNA1081609 and SRA study SRP492553. Searching any of these in the dataset finder brings you back here.

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