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Single cell sequencing shows that Sox9-expressing cells populate most mesenchymal lineages postnatally in mouse bone

GSE259382 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/03 Platform GPL19057
Summary
In growing bones of mice, multiple cell types contribute to the osteoblast lineage, including growth plate chondrocytes, perichondrial cells and CXCL12-abundant reticular (CAR) marrow stromal cells. Here we use single cell RNA sequencing and lineage tracing to show that all these osteoblast precursors, even postnatally, derive from Sox9-expressing progenitors. We also characterize a distinct group of chondrocytes between the perichondrium and the columns of growth plate chondrocytes that contribute to the osteoblast lineage.
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Single cell RNA sequencing shows that cells expressing Sox9 postnatally populate most skeletal lineages in mouse bone
Smith NP, Janton C, Alcantara ACM et al. · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2025 · PMID 40143416 · doi:10.1093/jbmr/zjaf043
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Also filed as BioProject PRJNA1081390 and SRA study SRP492036. Searching any of these in the dataset finder brings you back here.

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