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Effects of depletion of EPAS1 and knocking down TNFSF10 in 786-O cell lines.

GSE259401 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/03/08 Platform GPL24676
Summary
VHL loss leads to the stabilization of hypoxia-inducible factor α (HIFα), which may drive various tumor-promoting pathways. Here, we depletion expression of HIF2α in 786-O and performed transcriptome profiling to assess the molecular impact. TRAIL represents a promising avenue for cancer therapy due to its ability to selectively target and kill tumor cells. However, its effectiveness is variable across different cancer types, even with some tumors exhibiting high levels of TRAIL expression. To investigate this situation, we used shRNA to target TNFSF10, aiming to understand its impact on tumor development.
Published in
Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma
Wang X, Duong L, Qin Y et al. · bioRxiv : the preprint server for biology 2025 · PMID 40501957 · doi:10.1101/2025.05.29.621197
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Also filed as BioProject PRJNA1081410 and SRA study SRP492123. Searching any of these in the dataset finder brings you back here.

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