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In vivo study of the Tim3-loss in breast cancer cells during metastasis

GSE260480 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/02 Platform GPL17021
Summary
In metastasis, the existence tumor cells overcoming the immune system during early organ seeding is crucial, yet the dynamics of tumor-immune interactions during micrometastasis remain unclear. Examining the immune selective pressure in breast cancer (BC) mouse models, we unexpectedly found TIM3 among the most upregulated genes in metastatic surviving BC cells. The selection of TIM3+ tumor cells, was specifically occurring during early seeding of micrometastasis, escaping the immune attack and acquiring stemness. Also clinical data confirmed increased TIM3+ tumor cells in BC metastasis. The aim of the study was to understand the mechanistic insgihts of Tim3 in breast cancer cells in vivo to decipher pivotal pathways of Tim3-mediated immun-evasion.
Published in
TIM3(+) breast cancer cells license immune evasion during micrometastasis outbreak
Rozalén C, Sangrador I, Avalle S et al. · Cancer cell 2025 · PMID 40645187 · doi:10.1016/j.ccell.2025.06.015
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Also filed as BioProject PRJNA1081859 and SRA study SRP492360. Searching any of these in the dataset finder brings you back here.

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