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Gene expression profile at single cell level of CD45+ immune cells from 4TO7 cells (Ctrl or Tim3-KD) liver metastasis at different timepoints

GSE260482 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/02 Platform GPL24247
Summary
In this study we describe the immunosupressive role of Tim3+ tumor cells during eraly stages of metastasis. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of immune cells subsets altered by Tim3 expression in the tumor cells. The aim was to determine the immune status of immunosuppressive and cytotoxic populations during the dynamic process of the metastatic colonization in the liver
Published in
TIM3(+) breast cancer cells license immune evasion during micrometastasis outbreak
Rozalén C, Sangrador I, Avalle S et al. · Cancer cell 2025 · PMID 40645187 · doi:10.1016/j.ccell.2025.06.015
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Also filed as BioProject PRJNA1081867 and SRA study SRP492373. Searching any of these in the dataset finder brings you back here.

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