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ATAC-seq of TNF-alpha activation in HEK cells with or without TRAFTAC against NfkB

GSE260504 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/03/04 Platform GPL24247
Summary
TRAnscription Factor TArgeting Chimeras (TRAFTACs) can downregulated specific transcription factors at the protein-level through their DNA-binding affinity. We tested a previously validated TRAFTAC (Samarasinghe et al., 2021) against NFkB in the context of TNF-alpha activation in HEK cells, and profiled DNA accessibility using ATAC-seq.
Published in
On the identification of differentially-active transcription factors from ATAC-seq data
Gerbaldo FE, Sonder E, Fischer V et al. · PLoS computational biology 2024 · PMID 39441876 · doi:10.1371/journal.pcbi.1011971
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Also filed as BioProject PRJNA1081902 and SRA study SRP492394. Searching any of these in the dataset finder brings you back here.

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