Combined effects of genetic background and diet on mouse metabolism and gene expression
RNA-seq (gene expression) · mouse · 160 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 160 samples: 160 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Combined effects of genetic background and diet on mouse metabolism and gene expressioniScience · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE260764_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1083420 and SRA study SRP493146. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 160 sample titles: 160 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8123923 Mouse 1, Brown Adipose, C57BL/6J, American
- GSM8123924 Mouse 12, Brown Adipose, C57BL/6J, Vegetarian
- GSM8123925 Mouse 13, Brown Adipose, C57BL/6J, Vegan
- GSM8123926 Mouse 16, Brown Adipose, C57BL/6J, Vegan
- GSM8123927 Mouse 17, Brown Adipose, A/J, American
- GSM8123928 Mouse 18, Brown Adipose, A/J, American
- GSM8123929 Mouse 2, Brown Adipose, C57BL/6J, American
- GSM8123930 Mouse 22, Brown Adipose, A/J, Mediterranean
- GSM8123931 Mouse 24, Brown Adipose, A/J, Mediterranean
- GSM8123932 Mouse 25, Brown Adipose, A/J, Vegetarian
- GSM8123933 Mouse 27, Brown Adipose, A/J, Vegetarian
- GSM8123934 Mouse 30, Brown Adipose, A/J, Vegan
- GSM8123935 Mouse 32, Brown Adipose, A/J, Vegan
- GSM8123936 Mouse 33, Brown Adipose, DBA/2J, American
- GSM8123937 Mouse 34, Brown Adipose, DBA/2J, American
- GSM8123938 Mouse 38, Brown Adipose, DBA/2J, Mediterranean
- GSM8123939 Mouse 39, Brown Adipose, DBA/2J, Mediterranean
- GSM8123940 Mouse 42, Brown Adipose, DBA/2J, Vegetarian
- GSM8123941 Mouse 43, Brown Adipose, DBA/2J, Vegetarian
- GSM8123942 Mouse 45, Brown Adipose, DBA/2J, Vegan
- GSM8123943 Mouse 48, Brown Adipose, DBA/2J, Vegan
- GSM8123944 Mouse 49, Brown Adipose, SJL, American
- GSM8123945 Mouse 50, Brown Adipose, SJL, American
- GSM8123946 Mouse 53, Brown Adipose, SJL, Mediterranean
- GSM8123947 Mouse 54, Brown Adipose, SJL, Mediterranean
- GSM8123948 Mouse 57, Brown Adipose, SJL, Vegetarian
- GSM8123949 Mouse 59, Brown Adipose, SJL, Vegetarian
- GSM8123950 Mouse 63, Brown Adipose, SJL, Vegan
- GSM8123951 Mouse 64, Brown Adipose, SJL, Vegan
- GSM8123952 Mouse 7, Brown Adipose, C57BL/6J, Mediterranean
- GSM8123953 Mouse 8, Brown Adipose, C57BL/6J, Mediterranean
- GSM8123954 Mouse 9, Brown Adipose, C57BL/6J, Vegetarian
- GSM8123955 Mouse 1, Liver, C57BL/6J, American
- GSM8123956 Mouse 12, Liver, C57BL/6J, Vegetarian
- GSM8123957 Mouse 13, Liver, C57BL/6J, Vegan
- GSM8123958 Mouse 16, Liver, C57BL/6J, Vegan
- GSM8123959 Mouse 17, Liver, A/J, American
- GSM8123960 Mouse 18, Liver, A/J, American
- GSM8123961 Mouse 2, Liver, C57BL/6J, American
- GSM8123962 Mouse 22, Liver, A/J, Mediterranean
+ 120 more — browse all 160 samples with per-sample file links →
- GSE231992 Diet-induced obesity dysregulates rapid epigenetic response to hypoxia in macrophages (RNA-Seq) 12 samples shares genetic, diet
- GSE271883 Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development [ATAC-Seq] 12 samples shares genetic, diet
- GSE302447 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity 67 samples shares diet
- GSE243008 Mitochondrial serine metabolism fuels epigenetic remodelling in osteoclast differentiation and is the main target of methotrexate 58 samples shares genetic
- GSE315019 DTMB mitigates diet-induced metabolic dysfunction-associated steatohepatitis by targeting inflammation and lipid metabolism 22 samples shares diet
- GSE302441 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 2] 16 samples shares diet
- GSE320214 A Ketogenic Diet Sensitizes Pancreatic Cancer to Glutamine Metabolism Inhibitors 10 samples shares diet
- GSE302440 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 1] 8 samples shares diet
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.