A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 1]
RNA-seq (gene expression) · mouse · 8 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 8 samples: 4 × Liver, HFD, ctrl, vs 4 × Liver, HFD, TOFA,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE302440_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1290931 and SRA study SRP600516. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 2 replicated groups read from 8 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9104081 Liver, HFD, ctrl, rep1 Liver, HFD, ctrl,
- GSM9104082 Liver, HFD, ctrl, rep2 Liver, HFD, ctrl,
- GSM9104083 Liver, HFD, ctrl, rep3 Liver, HFD, ctrl,
- GSM9104084 Liver, HFD, ctrl, rep4 Liver, HFD, ctrl,
- GSM9104085 Liver, HFD, TOFA, rep1 Liver, HFD, TOFA,
- GSM9104086 Liver, HFD, TOFA, rep2 Liver, HFD, TOFA,
- GSM9104087 Liver, HFD, TOFA, rep3 Liver, HFD, TOFA,
- GSM9104088 Liver, HFD, TOFA, rep4 Liver, HFD, TOFA,
- GSE302447 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity 67 samples shares multi-functional, diet-induced, targeting, treatment, molecule, obesity, energy, small
- GSE302441 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 2] 16 samples shares multi-functional, diet-induced, targeting, treatment, molecule, obesity, energy, small
- GSE262523 Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Liver and Adipose Tissue in Mice 48 samples shares diet-induced, obesity
- GSE252343 Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity 34 samples shares diet-induced, obesity
- GSE315007 Sex- and hepatocyte Pparg-dependent hepatic effects of a high fat diet containing 60% kcal from fat and 2% cholesterol, which was supplemented with 10% fructose in the drinking water (HFC+Fr) to induce diet-induced obesity in male and female mice. 30 samples shares diet-induced, obesity
- GSE269328 Glucagon receptor agonism and treatment withdrawal effect on liver transcriptomes of diet-induced obese mice 24 samples shares diet-induced, treatment
- GSE315019 DTMB mitigates diet-induced metabolic dysfunction-associated steatohepatitis by targeting inflammation and lipid metabolism 22 samples shares diet-induced, targeting
- GSE269053 Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension 21 samples shares diet-induced, obesity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.