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EHF is an essential regulator of mammary alveolar lineage differentiation and putative suppressor of breast tumorigenesis

GSE260878 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2024/04/28 Platform GPL19057
Summary
The Ets homologous factor (Ehf) is highly expressed in the mammary gland in pregnancy and lactation. Mothers with Ehf deletion fail to lactate due to impaired lobuloalveolar development. ATACseq profiling of luminal mammary epithelial cells at late pregnancy (18.5dP) demonstrated that loss of Ehf results in significant chromatin remodelling.
Published in
Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis
Nightingale R, Reehorst CM, Vukelic N et al. · Developmental cell 2024 · PMID 38781975 · doi:10.1016/j.devcel.2024.04.022
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Also filed as BioProject PRJNA1083897 and SRA study SRP493487. Searching any of these in the dataset finder brings you back here.

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